Calcium-SANDOZ®-induced erythrocyte exovesiculation and internalization of hemichromic material into rat brown adipocytes

M. Markelić, K. Veličković, I. Golić, M. Ukropina, M. Čakić-Milošević, V. Koko and A. Korać
Archives of Biological Sciences, 63 (2011), 309-317.

Abstract. An ultramicroscopic study of brown adipose tissue (BAT) of rats treated with Ca-SANDOZ® (480 mg/l) for 3 days, revealed erythrocyte exovesiculation and migratory erythrocytic complexes from the capillaries to adipocyte cytoplasm and mitochondria. Two types of erythrocytic material transfer were observed: (i) numerous exocytic vesicles with electron dense material leaving the erythrocytes; (ii) furcated complexes with microholes, embedded in amorphous material. The content of red blood cell (RBC) complexes passed through the capillaries and transferred to the brown adipocytes where it was detectable in the cytoplasm and mitochondria. Light microscopy confirmed sphenoechinocytic transformation of the RBCs in the blood smears of the Ca-SANDOZ® treated rats.

Keywords: exovesiculation, red blood cell, brown adipocyte, calcium, hemoglobin, mitochondria

IF: 0.360
IF5: 0.606
MNTR classification: M23

BibTeX:

@article{markelic2011-abs,
  title = {Calcium-SANDOZ{\textregistered}-induced erythrocyte exovesiculation and internalization of hemichromic material into rat brown adipocytes},
  author = {Markelic, Milica and Velickovic, Ksenija and Golic, Igor and Ukropina, Mirela and Cakic-Milosevic, Maja and Koko, Vesna and Korac, Aleksandra},
  journal = {Archives of Biological Sciences},
  volume = {63},
  number = {2},
  pages = {309--317},
  year = {2011}
}