Is Manganese (II) Pentaazamacrocyclic Superoxide Dismutase Mimic Beneficial for Human Sperm Mitochondria Function and Motility?

V. Otasevic, A. Korac, M. Vucetic, B. Macanovic, E. Garalejic, I. Ivanovic-Burmazovic, M. R. Filipovic, B. Buzadzic, A. Stancic, A. Jankovic, K. Velickovic, I. Golic, M. Markelic and B. Korac
Antioxidants & Redox Signaling, 18 (2012), 170-178.

Abstract. Mitochondria play an important role in sperm cell maturation and function. Here, we examined whether (and how) changes in sperm redox milieu affect the functional status of sperm mitochondria, that is, sperm functionality. Compared with the control, incubation in Tyrode’s medium for 3 h, under noncapacitating conditions, decreased sperm motility, the amount of nitric oxide (•NO), the number of MitoTracker® Green FM (MT-G) positive mitochondria, and the expression of complexes I and IV of the mitochondrial respiratory chain. In turn, superoxide dismutase (SOD) mimic (M40403) treatment restored/increased these parameters, as well as the expression of endothelial nitric oxide synthase, manganese SOD, and catalase. These data lead to the hypothesis that M40403 improves mitochondrial functional state and motility of spermatozoa, as well as •NO might be involved in the observed effects of the mimic.

IF: 7.189
IF5: 7.548
MNTR classification: M21a


  title = {Is manganese (II) pentaazamacrocyclic superoxide dismutase mimic beneficial for human sperm mitochondria function and motility?},
  author = {Otasevic, Vesna and Korac, Aleksandra and Vucetic, Milica and Macanovic, Biljana and Garalejic, Eliana and Ivanovic-Burmazovic, Ivana and Filipovic, Milos R and Buzadzic, Biljana and Stancic, Ana and Jankovic, Aleksandra and others},
  year = {2012},
  journal = {Antioxidants & Redox Signaling},
  volume = {18},
  pages = {170--178}