Protein expression of ubiquitin in interscapular brown adipose tissue during acclimation of rats to cold: the impact of ∙NO

M. Vucetic, V. Otasevic, A. Stancic, A. Jankovic, M. Markelic, I. Golic, K. Velickovic, B. Buzadzic, A. Korac and B. Korac
Molecular and Cellular Biochemistry, 368 (2012), 189-193.

Abstract. In this study, the effects of l-arginine-nitric-oxide (∙NO)-producing pathway on protein content of ubiquitin, as an important component of ubiquitin–proteasome system for protein removal, were investigated. We showed that l-arginine markedly decreased ubiquitin protein content in interscapular brown adipose tissue, both in thermogenic inactive (at room temperature) and thermogenic active (on cold) states; while in l-NAME-treated groups this effect was abolished. This result suggests that nitric oxide (∙NO), besides well established roles, is involved in this aspect of structure remodeling, as well.

Keywords: L-arginine, nitric oxide, ubiquitin, brown adipose tissue, cold-acclimation

IF: 2.329
IF5: 2.185
MNTR classification: M23

BibTeX:

@Article{vucetic2012-mcb,
	author = {Vucetic, Milica and Otasevic, Vesna and Stancic, Ana and Jankovic, Aleksandra and Markelic, Milica and Golic, Igor and Velickovic, Ksenija and Buzadzic, Biljana and Korac, Aleksandra and Korac, Bato"}
	title = {Protein expression of ubiquitin in interscapular brown adipose tissue during acclimation of rats to cold: the impact of ∙NO},
	journal = {Molecular and Cellular Biochemistry},
	year = {2012},
	volume = {368},
	number = {1},
	pages = {189--193"},
	doi = {10.1007/s11010-012-1359-y}
}